From Florence : 

Take Highway A1 direction Arezzo.

From Arezzo follow signs for Sansepolcro and continue for Caprese Michelangelo.

From Rome :

Take Highway A1 and take exit Orte.

From Orte: follow the signs for E45 Highway direction Cesena. Take the exit Sansepolcro.

From the exit follow signs for Caprese Michelangelo.

From Bologna:

Take Highway A14  direction Ancona exit Cesena Nord.

Take the Highway E45 direction Rome exit Pieve S. Stefano Nord. From the exit follow signs for Caprese Michelangelo